In rats, higher nitrate levels in blood and saliva were linked to lower blood pressure, showing how the body's nitrate system might help control blood pressure.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is an animal model showing association between nitrate levels and blood pressure. The verb 'was inversely correlated' is appropriate for this correlational finding in an animal study.

Evidence from Studies

Supporting (1)

Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats

Randomized Controlled Trial

Animal

2025 Jul 23

Contradicting (0)

No contradicting evidence found

Source Study

Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats

Score: 16

DOI: 10.1038/s41598-025-12060-0

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