In rats prone to high blood pressure, the types and amounts of bacteria in the mouth are affected by the rat's genetic makeup.

Scientific Claim

Oral microbiota composition is influenced by host genetics in rats with genetic predisposition to hypertension.

Original Statement

“the abundance of oral Actinobacteria was upregulated by the BP locus on RNO10 in both sexes”

From study:Beyond the Gastrointestinal Tract: Oral and Sex-Specific Skin Microbiota Are Associated with Hypertension in Rats with Genetic Disparities.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study demonstrates statistical association between specific genetic loci and oral microbiota composition. The language 'upregulated by the BP locus' correctly reflects the correlational nature of the finding without implying direct causation.

Evidence from Studies

Supporting (1)

Beyond the Gastrointestinal Tract: Oral and Sex-Specific Skin Microbiota Are Associated with Hypertension in Rats with Genetic Disparities.

Cohort Study

Animal

2022 Jul 1

Contradicting (0)

No contradicting evidence found

Source Study

Beyond the Gastrointestinal Tract: Oral and Sex-Specific Skin Microbiota Are Associated with Hypertension in Rats with Genetic Disparities.

Score: 12

DOI: 10.1152/physiolgenomics.00169.2021

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