Giving BCAA supplements to rats with liver disease might help them keep more muscle, and it’s linked to changes in certain bile acids in their blood.

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Cross-Sectional Study

Human & Animal & In Vitro

2022 Oct 7

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Score: 51

DOI: 10.7554/eLife.80638

Similar Assertions

In people with long-term liver disease, having more of a certain gut-related acid in the blood might be linked to having more leg muscle strength — and this acid could help doctors spot muscle loss early.

72%

People sell BCAA supplements saying they help you build muscle and get stronger, but scientists aren’t sure if they really work because some studies say yes and others say no.

72%