In people with long-term liver disease, having more of a certain gut-related acid in the blood might be linked to having more leg muscle strength — and this acid could help doctors spot muscle loss...

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Evidence from Studies

Supporting (1)

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Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Cross-Sectional Study

Human & Animal & In Vitro

2022 Oct 7

Contradicting (0)

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No contradicting evidence found

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Source Study

Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Score: 51

DOI: 10.7554/eLife.80638

Similar Assertions

Higher levels of a substance called lithocholic acid in the blood might mean better survival for people with chronic liver disease — one study found that patients with levels above 0.32 had better outcomes over about 3 years.

72%

Giving BCAA supplements to rats with liver disease might help them keep more muscle, and it’s linked to changes in certain bile acids in their blood.

72%