In women, most genes linked to body fat (75%) didn't affect cholesterol, triglycerides, diabetes, or heart disease risk.

Scientific Claim

Among 174 autosomal body fat percentage loci in females, 75% (132 loci) showed no association with high-density lipoprotein cholesterol, triglycerides, type 2 diabetes, or coronary artery disease.

Original Statement

“Of 174 autosomal SNPs associated with BFPAdj in females, the majority (132, 75%) did not associate with cardiometabolic phenotypes.”

From study:Beyond apples and pears: sex-specific genetics of body fat percentage

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly reports the percentage of loci without association with cardiometabolic traits, using appropriate association language for observational data.

Evidence from Studies

Supporting (1)

Beyond apples and pears: sex-specific genetics of body fat percentage

Cross-Sectional Study

Human

2023

Contradicting (0)

No contradicting evidence found

Source Study

Beyond apples and pears: sex-specific genetics of body fat percentage

Score: 49

DOI: 10.3389/fendo.2023.1274791

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