When people train a muscle group more frequently—increasing from 8 to 12 sets per week—they gain about 0.9% more muscle mass, according to a review of multiple studies.
Mechanism
Synthesis from 1 study
Doing more sets per week — like going from 8 to 12 — pulls on your muscles just enough to turn on a molecular signal that tells your muscle cells to make more building proteins, which slowly makes them bigger, as shown in the study with older adults doing more leg exercises...
Most probable mechanism
When you do more sets of strength training each week, the repeated stretching and pulling on your muscles sends signals that turn on a molecular switch called mTOR, which then activates p70S6K — this helps your muscle cells make more proteins that build muscle fibers, leading to slightly bigger muscles over time, as shown in studies where increasing training volume from 8 to 12 sets per week led to measurable growth (10.1152/japplphysiol.00670.2023).
Mechanical tension from increased resistance training volume activates mechanosensitive structures in skeletal muscle fibers, initiating intracellular signaling (10.1152/japplphysiol.00670.2023)
Mechanotransduction signals converge on the mTORC1 complex, promoting its activation in response to higher training volume (10.1152/japplphysiol.00670.2023)
Activated mTORC1 phosphorylates p70S6K, enhancing its activity as a key regulator of ribosomal biogenesis and translation initiation (10.1152/japplphysiol.00670.2023)
Phosphorylated p70S6K increases the capacity for protein synthesis by upregulating ribosomal function and translation efficiency, leading to elevated myofibrillar protein synthesis rates (10.1152/japplphysiol.00670.2023)
Sustained net positive myofibrillar protein balance over weeks of higher-volume training results in incremental myofiber hypertrophy and increased muscle cross-sectional area (10.1152/japplphysiol.00670.2023)
Evidence from Studies
Supporting (1)
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Higher resistance training volume offsets muscle hypertrophy non-responsiveness in older individuals.
Contradicting (0)
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