The Claim
Insulin suppresses hormone-sensitive lipase, thereby inhibiting the hydrolysis of intracellular triglycerides into free fatty acids for energy utilization.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Insulin reduces the breakdown of stored fat into fatty acids by inhibiting an enzyme called hormone-sensitive lipase.
See the scientific wording
Insulin suppresses hormone-sensitive lipase, thereby inhibiting the hydrolysis of intracellular triglycerides into free fatty acids for energy utilization.
Insulin binds to fat cells and turns down a signal that tells the cell to break down stored fat. This causes enzymes that cut fat into fatty acids to become inactive, so fat stays stored instead of being released for energy.
What the research says
3 studiesStudy: Adipose Tissue Resistance to the Antilipolytic Effect of Insulin and Niacin in Humans With Obesity.
Insulin tells fat cells to stop breaking down stored fat into fatty acids, and this study shows that in obese and diabetic people, insulin still does this job well — even if the signal path inside the cell is a bit messed up.
Study: RELATIONSHIP BETWEEN A SEDENTARY LIFESTYLE AND ADIPOSE INSULIN RESISTANCE.
Insulin normally tells fat cells to stop breaking down stored fat into fatty acids. This study shows that in people who sit a lot, fat cells don’t respond as well to insulin, so more fat gets broken down — but insulin still tries to do its job, just less effectively.
Related videos
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 3 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.