If you keep your muscle while losing weight with certain diabetes or weight-loss drugs, you might be less likely to gain the weight back after stopping the drug — because more muscle helps you burn more calories even when resting.

If you keep your muscle while losing weight with certain diabetes or weight-loss drugs like semaglutide, you might be less likely to gain the weight back after stopping the drug — muscle could help keep your metabolism healthy long-term.

Medicines like semaglutide and tirzepatide help people lose a lot of weight—up to a quarter of their body weight—but they also cause some muscle loss, about as much as you’d normally lose in 10 years of aging.

If you're using diabetes or weight-loss drugs like semaglutide, adding personalized strength training can help you lose fat while keeping your muscle.

If older people lose a lot of muscle while taking weight-loss drugs like semaglutide or tirzepatide, it might raise their risk of weakness, falls, and even earlier death because muscle helps keep the body strong and burning calories.