Medicine and Exercise for Weight Loss
Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition?
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some new weight-loss medicines help people lose a lot of fat, but they also make them lose muscle. Muscle is important to stay strong and healthy, especially as we get older. Doing strength exercises like lifting weights can help keep muscle while losing fat.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some new weight-loss medicines help people lose a lot of fat, but they also make them lose muscle. Muscle is important to stay strong and healthy, especially as we get older. Doing strength exercises like lifting weights can help keep muscle while losing fat.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Publication
Authors
Locatelli JC, Costa JG, Haynes A, Naylor LH, Fegan PG, Yeap BB, Green DJ
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Claims (10)
A drug called retatrutide helps people lose a lot of weight—sometimes over 70 pounds—by targeting certain hormones, but it works so well that it can cause unexpected health problems.
Some newer weight-loss drugs help people lose a lot of weight—up to a quarter of their body weight—but they might also cause a big drop in muscle, about as much as people usually lose in 10 years of aging, which could make them weaker over time.
If adults do guided strength training for over 10 weeks, they might gain around 3 kilograms of muscle and get 25% stronger — and this could help balance out muscle loss from weight-loss drugs.
If you lose weight on a low-calorie diet, you're more likely to keep it off if you combine liraglutide with aerobic exercise, rather than doing just one of those things — the exercise seems to boost how well the medication works over time.
If you keep your muscle while losing weight with certain diabetes or weight-loss drugs like semaglutide, you might be less likely to gain the weight back after stopping the drug — muscle could help keep your metabolism healthy long-term.