A drug called retatrutide helps people lose a lot of weight—sometimes over 70 pounds—by targeting certain hormones, but it works so well that it can cause unexpected health problems.

A drug called retatrutide probably helps people with obesity or type 2 diabetes lose about 14% of their body weight when given as a weekly shot for up to a year, and higher doses seem to lead to more weight loss.

Retatrutide keeps helping people lose weight steadily for a whole year without slowing down, while other weight-loss drugs like GLP-1s tend to stop working as well after a few months.

A new weight-loss drug called retatrutide might help people with obesity lose about a quarter of their body weight in less than a year—and it could work even better and faster than weight-loss surgery or other medicines we have now.

A diabetes drug called tirzepatide can help people lose up to 21% of their body weight, but the weight loss tends to stop increasing too soon — especially for those with type 2 diabetes.

Some new weight-loss drugs that work on two hormone receptors at once seem to help people lose a lot of weight and also improve liver health in those with fatty liver disease, based on early studies.