A drug called retatrutide helps people lose a lot of weight—sometimes over 70 pounds—by targeting certain hormones, but it works so well that it can cause unexpected health problems.

A drug called retatrutide probably helps people with obesity or type 2 diabetes lose about 14% of their body weight when given as a weekly shot for up to a year, and higher doses seem to lead to more weight loss.

Retatrutide keeps helping people lose weight steadily for a whole year without slowing down, while other weight-loss drugs like GLP-1s tend to stop working as well after a few months.

A new weight-loss drug called retatrutide might help people with obesity lose about a quarter of their body weight in less than a year—and it could work even better and faster than weight-loss surgery or other medicines we have now.

Some diabetes and weight-loss drugs, like tirzepatide, can help people lose a lot of weight—up to nearly 18% more than a fake treatment over a year and a half—especially in those without diabetes, and they might also improve overall health.

GLP-1 receptor agonists trigger changes in the body that occur even when weight loss is accounted for, suggesting these drugs have effects beyond reducing body weight.