A drug called retatrutide probably helps people with obesity or type 2 diabetes lose about 14% of their body weight when given as a weekly shot for up to a year, and higher doses seem to lead to more weight loss.

A drug called retatrutide helps people lose a lot of weight—sometimes over 70 pounds—by targeting certain hormones, but it works so well that it can cause unexpected health problems.

A new weight-loss drug called retatrutide might help people with obesity lose about a quarter of their body weight in less than a year—and it could work even better and faster than weight-loss surgery or other medicines we have now.

Retatrutide keeps helping people lose weight steadily for a whole year without slowing down, while other weight-loss drugs like GLP-1s tend to stop working as well after a few months.

Adults with obesity or type 2 diabetes who take a weekly 12 mg dose of retatrutide are way more likely—over 70 times more—to lose at least 15% of their body weight in less than a year compared to those taking a fake pill.

People with obesity who took a shot called retatrutide once a week for a year lost nearly a quarter of their body weight—way more than those who got a dummy shot. This makes it one of the strongest weight-loss medicines we’ve seen so far.