quantitative
Analysis v1
46
Pro
0
Against

Lifting light or heavy weights until failure doesn’t clearly make your fast-twitch muscle fibers bigger in your thighs — the data is too mixed to say one is better.

Scientific Claim

Low-load and high-load resistance training performed to muscular failure show no statistically significant difference in type II muscle fiber hypertrophy in the quadriceps of young, untrained individuals, with a standardized mean difference of 0.30 (95% CI: -0.05 to 0.66), indicating the true effect could be trivial or moderately favorable to either training load.

Original Statement

In the meta-analysis for the effects of low-load vs. high-load resistance training on type II muscle fiber hypertrophy, there was no significant difference between the training conditions (standardized mean difference: 0.30; 95% confidence interval: –0.05, 0.66; p = 0.089; I² = 0%; 95% prediction interval: –0.28, 0.88).

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The authors correctly report non-significance and wide intervals, avoiding claims of equivalence. The study design (meta-analysis of low-sample-size studies with unknown RCT status) only supports associative interpretation.

Evidence from Studies

Supporting (1)

46

This study found that lifting light weights and lifting heavy weights, both until you can't do another rep, result in about the same muscle growth in the thighs — neither is clearly better.

Contradicting (0)

0
No contradicting evidence found