correlational
Analysis v1
Strong Support
People born with a certain gene that lowers their bad cholesterol their whole life have a lower risk of heart disease than what we'd expect from cholesterol-lowering drugs like statins — meaning starting early and keeping cholesterol low for longer might protect the heart better.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.
Cohort Study
Human
2006 Mar 23People born with certain PCSK9 gene changes have lower cholesterol their whole lives and are much less likely to get heart disease, even more than expected from cholesterol-lowering drugs, suggesting early and long-term lowering helps more.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.