The Claim

In mice with non-alcoholic fatty liver disease, a ketogenic diet supplemented with branched-chain amino acids is associated with a 30-50% reduction in deuterium incorporation into hepatic lipids, indicating suppressed de novo lipogenesis compared to high-fat diet controls.

Source: Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
9score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
1 study reviewed
In plain English

When mice with fatty liver disease eat a special low-carb diet with certain amino acids, their livers make 30-50% less new fat compared to mice eating high-fat food.

See the scientific wording

A ketogenic diet with BCAAs in mice with NAFLD is associated with reduced hepatic de novo lipogenesis, with deuterium incorporation into lipids decreased by 30-50% compared to high-fat diet controls, indicating suppression of new fat synthesis in the liver.

What the research says

1 study

  1. Study: Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD

    The study gave mice a keto diet with extra amino acids and found it reduced new fat production in the liver, which supports the claim, but didn't measure the exact 30-50% decrease mentioned.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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