Ketogenic Diet Worsens Fatty Liver in Mice
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Ketogenic diet worsened liver injury despite increasing fat oxidation.
Contradicts the common belief that ketogenic diets reduce liver fat and improve health in metabolic diseases.
Practical Takeaways
Consult a healthcare provider before starting a ketogenic diet if you have fatty liver disease.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Ketogenic diet worsened liver injury despite increasing fat oxidation.
Contradicts the common belief that ketogenic diets reduce liver fat and improve health in metabolic diseases.
Practical Takeaways
Consult a healthcare provider before starting a ketogenic diet if you have fatty liver disease.
Publication
Journal
The FASEB Journal
Year
2020
Authors
M. S. Muyyarikkandy, Marc McLeod, Meghan Maguire, Rohit Mahar, Nathan Kattapuram, Christine Zhang, Chaitra Surugihalli, V. Muralidaran, Kruthi Vavilikolanu, C. Mathews, M. Merritt, N. Sunny
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Claims (10)
Eating fewer carbs might make your liver produce more sugar, and some scientists think this could put extra strain on your liver.
When mice with fatty liver disease ate a special low-carb diet with extra amino acids, it didn't help their insulin problems. Their bodies still handled sugar poorly, just like mice on a high-fat diet.
In mice with fatty liver disease, a special diet with certain nutrients and less carbs seems to boost the liver's ability to make ketones, which are energy molecules. This diet made ketone production about 50-100% higher than just a high-fat diet.
When mice with fatty liver disease eat a special low-carb diet with certain amino acids, their livers make 30-50% less new fat compared to mice eating high-fat food.
In mice with fatty liver disease, a special diet with certain amino acids helps slow down the liver's fat-making process, cutting fat production by almost half compared to a high-fat diet.