When middle-aged mice don't get enough vitamin D, their blood sugar control gets worse in the evening, but giving them quercetin—a plant compound—doesn't help fix it.

14

Pro

0

Against

Evidence from Studies

Supporting (1)

14

Community contributions welcome

14

Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet

Randomized Controlled Trial

Animal

2024 Feb

The study gave vitamin D-deficient mice quercetin and found that, even with the supplement, their insulin and insulin resistance stayed high — just like the claim said. So quercetin didn’t fix those problems.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet

Score: 14

DOI: 10.1007/s13105-023-00990-0

Similar Assertions

When older mice don't get enough vitamin D, giving them quercetin (a plant compound) changes some of their body clock genes and increases a key clock protein at a specific time of day—but if the mice have enough vitamin D, quercetin doesn't do anything noticeable.

14

0

75%

When older mice don't get enough vitamin D, giving them quercetin (a plant compound) makes a key body clock gene less active at a specific time of day—but only when they're also low on vitamin D. If they have enough vitamin D or don't get quercetin, this doesn't happen.

14

0

72%