mechanistic
Analysis v1
Strong Support
When older mice don't get enough vitamin D, giving them quercetin (a plant compound) makes a key body clock gene less active at a specific time of day—but only when they're also low on vitamin D. If they have enough vitamin D or don't get quercetin, this doesn't happen.
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Evidence from Studies
Supporting (1)
14
Community contributions welcome
14
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet
Randomized Controlled Trial
Animal
2024 FebIn mice that didn’t get enough vitamin D, giving them quercetin made a key body clock gene (Bmal1) less active at a specific time of day — more than when they got quercetin alone or nothing at all. This shows quercetin works differently depending on the diet.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.