Mice with the ApoE4 gene make less of the proteins that help create and move certain brain fats, even when eating a normal diet.

9

Pro

0

Against

Evidence from Studies

Supporting (1)

9

Community contributions welcome

9

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

Cohort Study

Animal

2017

Scientists found that mice with a human gene linked to Alzheimer’s (ApoE4) had less of certain key molecules involved in fat processing in the brain—compared to normal mice and mice without the gene—when they ate regular food.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Source Study

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

Score: 9

DOI: 10.3233/JAD-160739

Similar Assertions

When mice with the ApoE4 gene eat a fatty, cholesterol-rich diet, their brains accumulate more saturated fats than when they eat normal food.

9

0

80%

When mice eat a fatty diet, the genes that make brain fats shut down in normal mice and ApoE4 mice—but not in mice that have no ApoE gene at all.

9

0

74%