When mice with the ApoE4 gene eat a fatty, cholesterol-rich diet, their brains accumulate more saturated fats than when they eat normal food.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

Cohort Study

Animal

2017

Scientists found that mice with a human gene linked to Alzheimer’s (ApoE4) had more bad fats in their brains when fed a fatty, high-cholesterol diet compared to when they ate normal food.

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No contradicting evidence found

Source Study

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

Score: 9

DOI: 10.3233/JAD-160739

Similar Assertions

Mice with the ApoE4 gene make less of the proteins that help create and move certain brain fats, even when eating a normal diet.

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80%

When mice eat a fatty diet, the genes that make brain fats shut down in normal mice and ApoE4 mice—but not in mice that have no ApoE gene at all.

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74%

A fatty diet turns down the genes that move fats around in normal mice, but not in mice that don’t have the ApoE gene.

9

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71%