When mice eat a fatty diet, the genes that make brain fats shut down in normal mice and ApoE4 mice—but not in mice that have no ApoE gene at all.

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Evidence from Studies

Supporting (1)

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Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

Cohort Study

Animal

2017

The study found that eating a high-fat, high-cholesterol diet lowers certain fat-related genes in normal mice and mice with a human Alzheimer’s risk gene, but not in mice that completely lack the ApoE gene — meaning ApoE is needed for this effect.

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Source Study

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

Score: 9

DOI: 10.3233/JAD-160739

Similar Assertions

A fatty diet turns down the genes that move fats around in normal mice, but not in mice that don’t have the ApoE gene.

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89%

Mice with the ApoE4 gene make less of the proteins that help create and move certain brain fats, even when eating a normal diet.

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74%

When mice with the ApoE4 gene eat a fatty, cholesterol-rich diet, their brains accumulate more saturated fats than when they eat normal food.

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74%