Mitochondrial health connects fat loss and performance, and when mitochondria work better, fat loss happens naturally. Peptide stacking only makes sense when the mechanisms are different, like tesamorelin (growth hormone/IGF-1) and MOTS-c (AMPK/mitochondrial energy sensing), which work through different pathways to improve mitochondrial function.

“So, mitochondrial health is the bridge between fat loss and performance. And when mitochondria work better, fat loss becomes a downstream effect and not so much a fight. Like, it's just happening in natural harmony. So, it's important to know like when you're stacking peptides in general, stacking only makes sense when the mechanisms are different. Okay? So like don't just load up on a bunch of growth hormone uh secretreting peptides. That doesn't like make sense. You're just stacking on top of one another. You want to stack when the mechanisms are different. So tesmarillan works through grow growth hormone and IGF-1 whereas Matsi works through EMPK and mitochondrial energy sensing. So different pathways but the same direction just like fasting is good for the mitochondria and exercise is good for the mitochondria but they're not the same thing.”