Tesamorelin and MOTS-c work together synergistically: tesamorelin helps mobilize and improve fat quality and mitochondrial capacity, while MOTS-c improves how efficiently mitochondria use the fuel, creating a supply-and-utilization synergy.
Scientific Claim
Tesamorelin and MOTS-c act synergistically: tesamorelin enhances fat mobilization, fat quality, and mitochondrial capacity for fat burning, while MOTS-c improves mitochondrial fuel utilization efficiency through AMPK activation, creating a complementary supply-and-utilization mechanism.
Original Statement
“So think about this pairing and how this works. Tessamellin improves fat mobilization, how the fat's moving around. It improves the fat quality. It improves the mitochondrial capacity to actually burn the fat. And then M C improves how efficiently the mitochondria uses the fuel. So one supports supply, the other's kind of supporting utilization. That's not really redundancy, that's more synergy. That's them working together.”
Context Details
Domain
pharmacology
Population
mixed
Subject
tesamorelin and MOTS-c
Action
act synergistically
Target
by supporting fat mobilization and mitochondrial capacity (tesamorelin) and fuel utilization efficiency (MOTS-c)
Intervention Details
Evidence from Studies
Supporting (2)
This paper found that MOTS-c helps regulate metabolism and improve insulin sensitivity, which supports the idea that MOTS-c can help the body use energy more efficiently.
AGING MODULATION WITH EXERCISE AND MIMETICS
This paper talks about how exercise and some medicines can help activate a pathway in our bodies that makes us more efficient and healthy, which is related to how MOTS-c works.
Contradicting (3)
The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.
The study shows that one drug, tesamorelin, helps mitochondria work better in obese people, but it doesn’t mention the other drug (MOTS-c) or how they might work together, so we can’t say they boost each other like the claim says.
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.
This paper found that MOTS-c helps prevent muscle loss by reducing fat infiltration in muscles, but it doesn't directly test the combination of tesamorelin and MOTS-c on fat burning and mitochondrial efficiency.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
This study only talks about one molecule, MOTS-c, and how it helps the body use energy better — it doesn’t mention tesamorelin or say anything about them working together.