Tesamorelin turns on genes that help mitochondria burn fat more efficiently by improving oxidative phosphorylation and fatty acid oxidation, leading to cellular-level metabolic remodeling.
Scientific Claim
Tesamorelin upregulates genes involved in oxidative phosphorylation across the electron transport chain and in fatty acid oxidation, leading to cellular-level metabolic remodeling that enhances fat burning efficiency at the mitochondrial level.
Original Statement
“And now we're starting to understand why. Because there was another study in the journal clinical investigation that showed that Tesarellan upregulated the genes that were involved in oxidative phosphorylation across the electron transport chain along with genes that are involved in fatty acid oxidation. This is a big deal because this is not just like dropping belly fat or cosmetic fat loss. All this stuff means that you're having cellular level metabolic remodeling where you're burning fat better at a core level.”
Context Details
Domain
pharmacology
Population
unspecified
Subject
tesamorelin
Action
upregulates
Target
genes involved in oxidative phosphorylation and fatty acid oxidation
Intervention Details
Evidence from Studies
Supporting (2)
Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes.
The study found that increasing PGC-1α in human muscle cells increased the breakdown of fatty acids in mitochondria and peroxisomes, supporting the idea that Tesamorelin could enhance fat burning efficiency.
Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice
The research demonstrated that apelin treatment helped insulin-resistant mice burn fatty acids more efficiently and improved mitochondrial function, suggesting a similar potential benefit for Tesamorelin.