Tesamorelin improves fat quality by increasing fat density, meaning the fat tissue becomes healthier with smaller fat cells, better blood supply, and less inflammation, even after accounting for fat loss.
Scientific Claim
Tesamorelin independently increases fat density in visceral and subcutaneous adipose tissue, indicating improved fat quality with smaller adipocytes, better vascularization, reduced hypoxia, and decreased inflammation, independent of fat quantity changes.
Original Statement
“And here's where the story starts to get really interesting. Fat loss isn't just about how much fat you have. It's also about what kind of fat it is. That brings us to something known as fat quality. And another study that was published in AIDS looked at people who responded well to tessamellin and it analyzed changes in their fat density. Okay, not just their fat quantity. So even after accounting for how much visceral and subcutaneous fat people lost, tessamellin independently increased fat density. That means the fat tissue itself became healthier, smaller fat cells, you have better blood supply, uh less hypoxia and less inflammation in the actual fat cell.”
Context Details
Domain
pharmacology
Population
human
Subject
tesamorelin
Action
increases
Target
fat density in visceral and subcutaneous adipose tissue
Intervention Details
Evidence from Studies
Supporting (3)
Tesamorelin improves fat quality independent of changes in fat quantity
This study shows that tesamorelin improves the quality of fat in the body, making it healthier, even if the amount of fat doesn't change.
Tesamorelin improves fat quality independent of changes in fat quantity
Tesamorelin made fat cells smaller and healthier without necessarily reducing the amount of fat, which is good for your body’s metabolism.
Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV
This study found that tesamorelin not only reduces harmful visceral fat but also improves liver health in people with HIV.