The drug turns on genes that help mitochondria burn fat and make energy more efficiently.
Scientific Claim
Tesamorelin upregulates nuclear-encoded genes involved in mitochondrial oxidative phosphorylation and fatty acid β-oxidation.
Original Statement
“Tesamorelin upregulated the genes that were involved in oxidative phosphorylation across the electron transport chain along with genes that are involved in fatty acid oxidation.”
Context Details
Domain
pharmacology
Population
unspecified
Subject
Tesamorelin
Action
upregulates
Target
genes involved in oxidative phosphorylation and fatty acid oxidation
Intervention Details
Evidence from Studies
Supporting (0)
Contradicting (3)
Unknown Title
The study shows tesamorelin helps reduce belly fat, but it didn’t check if it turns on genes that help burn fat or make energy in cells, so we can’t say if the claim about genes is true.
The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.
The study shows that the drug helps muscles recover energy faster after exercise, which might mean mitochondria are working better—but it didn’t check if the genes responsible for that improvement were turned up.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
This study talks about a different molecule (MOTS-c) from mitochondria that helps control metabolism, but it doesn’t mention Tesamorelin or any genes it might turn on, so it doesn’t support the claim.