Apelin Helps Mice Burn Fat Better
Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a special protein called apelin to mice that were overweight and had trouble using sugar. After 4 weeks, the mice burned more fat, had less fat, lower blood sugar, and better insulin response. This happened because apelin made their muscles build more mitochondria (the cell’s power...
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
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Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a special protein called apelin to mice that were overweight and had trouble using sugar. After 4 weeks, the mice burned more fat, had less fat, lower blood sugar, and better insulin response. This happened because apelin made their muscles build more mitochondria (the cell’s power...
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 513 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Attané C, Foussal C, Le Gonidec S, Benani A, Daviaud D, Wanecq E, Guzmán-Ruiz R, Dray C, Bezaire V, Rancoule C, Kuba K, Ruiz-Gayo M, Levade T, Penninger J, Burcelin R, Pénicaud L, Valet P, Castan-Laurell I
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Claims (10)
Tesamorelin upregulates genes involved in oxidative phosphorylation across the electron transport chain and in fatty acid oxidation, leading to cellular-level metabolic remodeling that enhances fat burning efficiency at the mitochondrial level.
Giving apelin to obese, insulin-resistant mice for a month helps them lose body fat and lowers their blood sugar levels compared to mice given a placebo.
Apelin-treated mice burn fat more completely in their muscles compared to placebo-treated mice, reducing harmful fat byproducts.
Apelin helps mouse muscles use oxygen more efficiently for energy production, especially when using fat as fuel.
Apelin makes mouse muscles produce more mitochondria, the cell's energy factories, leading to better fat-burning capacity.