Giving apelin to obese, insulin-resistant mice for a month helps them lose body fat and lowers their blood sugar levels compared to mice given a placebo.

Apelin lowers blood fat levels and helps mice process sugar better, improving overall metabolic health.

Apelin-treated mice burn more fat for energy during active periods compared to placebo-treated mice, shown by their breathing patterns.

Apelin-treated mice burn fat more completely in their muscles compared to placebo-treated mice, reducing harmful fat byproducts.

Apelin activates a key energy-sensing enzyme in muscles, which helps reduce fat buildup and improve metabolism.

Apelin reduces harmful fat byproducts in muscles, which helps muscles take up more glucose in response to insulin.