Apelin lowers blood fat levels and helps mice process sugar better, improving overall metabolic health.
Scientific Claim
Chronic apelin treatment (0.1 μmol/kg/day intraperitoneally for 4 weeks) in high-fat diet-induced insulin-resistant mice is associated with reduced plasma triglyceride levels and improved glucose tolerance (n=12 per group, P ≤ 0.05).
Original Statement
“HFD apelin-treated mice also had significantly reduced adiposity and plasma levels of TG, whereas FA levels and leptin and adiponectin plasma concentrations were not modified (Table 1). ... apelin-treated mice were significantly more responsive to glucose and insulin at the end of the treatment (Fig. 1B and C).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim uses 'associated with' which correctly reflects the associative nature of the study design, avoiding causal language.
Evidence from Studies
Supporting (1)
Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice