Apelin activates a key energy-sensing enzyme in muscles, which helps reduce fat buildup and improve metabolism.

Apelin's benefits for fat burning and mitochondria in muscles only work when AMPK is active, as shown in genetically modified mice.

Apelin-treated mice burn fat more completely in their muscles compared to placebo-treated mice, reducing harmful fat byproducts.

Giving apelin to obese, insulin-resistant mice for a month helps them lose body fat and lowers their blood sugar levels compared to mice given a placebo.

Apelin lowers blood fat levels and helps mice process sugar better, improving overall metabolic health.

Apelin reduces harmful fat byproducts in muscles, which helps muscles take up more glucose in response to insulin.