Apelin's benefits for fat burning and mitochondria in muscles only work when AMPK is active, as shown in genetically modified mice.

Apelin activates a key energy-sensing enzyme in muscles, which helps reduce fat buildup and improve metabolism.

Apelin-treated mice burn fat more completely in their muscles compared to placebo-treated mice, reducing harmful fat byproducts.

Apelin helps mouse muscles use oxygen more efficiently for energy production, especially when using fat as fuel.

Apelin turns on genes that help build more mitochondria in muscles, improving energy production.

Apelin-treated mice burn more fat for energy during active periods compared to placebo-treated mice, shown by their breathing patterns.