Apelin helps mouse muscles use oxygen more efficiently for energy production, especially when using fat as fuel.
Scientific Claim
Chronic apelin treatment (0.1 μmol/kg/day intraperitoneally for 4 weeks) in high-fat diet-induced insulin-resistant mice is associated with higher mitochondrial oxidative capacity in soleus muscle, as evidenced by increased succinate-driven respiration (n=7 per group, P < 0.05).
Original Statement
“The succinate-driven mitochondrial respiration was significantly higher in fibers from apelin-treated mice compared with control, suggesting an increase in the oxidative capacity from complex II that uses coenzymes derived from FAO (Fig. 4A).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim uses 'associated with' which correctly reflects the associative nature of the study design, avoiding causal language.
Evidence from Studies
Supporting (1)
Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice