Apelin helps mouse muscles use oxygen more efficiently for energy production, especially when using fat as fuel.

Apelin-treated mice burn fat more completely in their muscles compared to placebo-treated mice, reducing harmful fat byproducts.

Apelin turns on genes that help build more mitochondria in muscles, improving energy production.

Apelin makes mouse muscles produce more mitochondria, the cell's energy factories, leading to better fat-burning capacity.

Apelin-treated mice burn more fat for energy during active periods compared to placebo-treated mice, shown by their breathing patterns.

Apelin activates a key energy-sensing enzyme in muscles, which helps reduce fat buildup and improve metabolism.