Apelin turns on genes that help build more mitochondria in muscles, improving energy production.

Apelin helps mouse muscles use oxygen more efficiently for energy production, especially when using fat as fuel.

Apelin makes mouse muscles produce more mitochondria, the cell's energy factories, leading to better fat-burning capacity.

Apelin-treated mice burn fat more completely in their muscles compared to placebo-treated mice, reducing harmful fat byproducts.

Apelin activates a key energy-sensing enzyme in muscles, which helps reduce fat buildup and improve metabolism.

Apelin's benefits for fat burning and mitochondria in muscles only work when AMPK is active, as shown in genetically modified mice.