MOTS-c helps mice burn fat better
The mitochondrial‐derived peptide MOTS‐c is a regulator of plasma metabolites and enhances insulin sensitivity
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a special peptide called MOTS-c to fat mice and found it helped their bodies burn fat more efficiently and lowered blood sugar. It changed levels of certain fats and chemicals in the blood that are linked to diabetes and obesity.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Max 90Cohort Studies
Max 72Case-Control Studies
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Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a special peptide called MOTS-c to fat mice and found it helped their bodies burn fat more efficiently and lowered blood sugar. It changed levels of certain fats and chemicals in the blood that are linked to diabetes and obesity.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 58 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P
Related Content
Claims (9)
Tesamorelin and MOTS-c act synergistically: tesamorelin enhances fat mobilization, fat quality, and mitochondrial capacity for fat burning, while MOTS-c improves mitochondrial fuel utilization efficiency through AMPK activation, creating a complementary supply-and-utilization mechanism.
Obese mice given MOTS-c injections for three days had lower blood sugar levels than mice that didn't receive the treatment.
MOTS-c injections in obese mice lowered a specific blood fat molecule called sphingosine 1-phosphate by about 14% compared to untreated mice.
Obese mice treated with MOTS-c had lower levels of a specific sphingolipid called palmitoyl sphingomyelin, which is associated with insulin resistance.
MOTS-c injections in obese mice reduced a type of fat molecule called 2-oleoylglycerol by about 32% compared to untreated mice.