quantitative
Analysis v1
8
0
Obese mice treated with MOTS-c had lower levels of a specific sphingolipid called palmitoyl sphingomyelin, which is associated with insulin resistance.
Scientific Claim
In diet-induced obese mice, MOTS-c injection was associated with a 23% reduction in palmitoyl sphingomyelin (d18:1/16:0) levels (fold change 0.77, P = 0.0067; n=6 per group).
Original Statement
“Palmitoyl sphingomyelin (d18:1/16:0)* (P = 0.0067; fold change = 0.77)”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design allows for association claims between treatment and outcome, but lacks randomization and blinding, so causal language is inappropriate. 'Associated with' correctly reflects the evidence.
Evidence from Studies
Supporting (1)
8
Contradicting (0)
0
No contradicting evidence found