MOTS-c helps muscles stay strong when inactive
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When mice can't move their legs, their muscles shrink. But giving them MOTS-c, a tiny protein from mitochondria, helps keep their muscles bigger and healthier. It does this by reducing fat buildup in muscles and lowering inflammation.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 516 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When mice can't move their legs, their muscles shrink. But giving them MOTS-c, a tiny protein from mitochondria, helps keep their muscles bigger and healthier. It does this by reducing fat buildup in muscles and lowering inflammation.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 516 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Kumagai H, Kim SJ, Miller B, Natsume T, Wan J, Kumagai ME, Ramirez R 2nd, Lee SH, Sato A, Mehta HH, Yen K, Cohen P
Related Content
Claims (10)
MOTS-c treatment reduced collagen buildup in the muscles of immobilized mice, which may help prevent stiffness.
MOTS-c lowered levels of myostatin, a protein that inhibits muscle growth, in the muscles of immobilized mice.
In immobilized mice, higher levels of MOTS-c in the muscles were linked to better muscle mass retention.
When mice had their legs immobilized for 8 days, giving them MOTS-c helped their muscles lose less weight (5% instead of 15%) compared to mice that didn't get the treatment.
MOTS-c helped maintain higher activity levels of key muscle signaling proteins (AKT, FOXO1, FOXO3a) in immobilized mice, which are important for muscle health.