MOTS-c lowered levels of myostatin, a protein that inhibits muscle growth, in the muscles of immobilized mice.

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Pro

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Against

Evidence from Studies

Supporting (1)

16

Community contributions welcome

16

Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Randomized Controlled Trial

Animal

2024 Mar 1

Contradicting (0)

0

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No contradicting evidence found

Source Study

Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Score: 16

DOI: 10.1152/ajpendo.00285.2023

Similar Assertions

When mice had their legs immobilized for 8 days, giving them MOTS-c helped their muscles lose less weight (5% instead of 15%) compared to mice that didn't get the treatment.

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92%

MOTS-c treatment lowered levels of myostatin, a protein that normally limits muscle growth, in immobilized mice.

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91%

MOTS-c treatment reduced collagen buildup in the muscles of immobilized mice, which may help prevent stiffness.

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88%

In immobilized mice, higher levels of MOTS-c in the muscles were linked to better muscle mass retention.

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88%

MOTS-c reduced the amount of fatty acids in the muscles of immobilized mice, which may prevent harmful fat buildup.

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88%