correlational
Analysis v1
16
0
In immobilized mice, higher levels of MOTS-c in the muscles were linked to better muscle mass retention.
Scientific Claim
In male C57BL/6J mice with 8 days of hindlimb cast immobilization, skeletal muscle mass was positively correlated with MOTS-c expression levels in skeletal muscle.
Original Statement
“skeletal muscle mass was positively correlated to the MOTS-c expression levels (Fig. 2D).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal cohort with no blinding confirmation, so causal language is inappropriate. The claim uses 'associated with' which correctly reflects the associative evidence.
Evidence from Studies
Supporting (1)
16
16
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.
Randomized Controlled Trial
Animal
2024 Mar 1Contradicting (0)
0
No contradicting evidence found