Mice with higher levels of MOTS-c in their muscles tended to have more muscle mass after immobilization.

Scientific Claim

In male C57BL/6J mice with 8 days of hindlimb immobilization, skeletal muscle MOTS-c expression levels were positively correlated with muscle mass.

Original Statement

“Skeletal muscle mass was positively correlated to the MOTS-c expression levels (Fig. 2D).”

From study:Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim uses 'positively correlated' which is appropriate for correlational data from the study.

Evidence from Studies

Supporting (1)

Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Randomized Controlled Trial

Animal

2024 Mar 1

Contradicting (0)

No contradicting evidence found

Source Study

Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Score: 16

DOI: 10.1152/ajpendo.00285.2023

Similar Assertions

In immobilized mice, higher levels of MOTS-c in the muscles were linked to better muscle mass retention.

97%

When mice had their legs immobilized for 8 days, giving them MOTS-c helped their muscles lose less weight (5% instead of 15%) compared to mice that didn't get the treatment.

88%

MOTS-c treatment reduced collagen buildup in the muscles of immobilized mice, which may help prevent stiffness.

85%

MOTS-c lowered levels of myostatin, a protein that inhibits muscle growth, in the muscles of immobilized mice.

84%

When mice had their legs immobilized for 8 days, giving them MOTS-c daily helped their muscles lose less weight—only 5% compared to 15% without treatment.

83%