MOTS-c reduced the amount of fatty acids in the muscles of immobilized mice, which may prevent harmful fat buildup.
Scientific Claim
In male C57BL/6J mice with 8 days of hindlimb cast immobilization, MOTS-c administration (15 mg/kg/day) was associated with lower skeletal muscle fatty acid levels compared to immobilized control mice.
Original Statement
“skeletal muscle fatty acid levels were significantly lower in the MOTS-c-treated group than in the immobilization control group (P < 0.05) (Fig. 5, C and D).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal cohort with no blinding confirmation, so causal language is inappropriate. The claim uses 'associated with' which correctly reflects the associative evidence.
Evidence from Studies
Supporting (1)
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.