MOTS-c didn't affect the triglyceride levels in the muscles of immobilized mice, even though it reduced fatty acids.
Scientific Claim
In male C57BL/6J mice with 8 days of hindlimb immobilization, daily MOTS-c administration (15 mg/kg/day) was not associated with significant changes in skeletal muscle triglyceride levels compared to untreated controls.
Original Statement
“Although triglyceride levels were not statistically different (P = 0.22), skeletal muscle fatty acid levels were significantly lower in the MOTS-c-treated group than in the immobilization control group (P < 0.05) (Fig. 5, C and D).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim uses 'was not associated with significant changes' which accurately reflects the non-significant result (P=0.22) from the study.
Evidence from Studies
Supporting (1)
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.