When people take semaglutide 2.4 mg, many feel sick to their stomach, throw up, or have constipation or diarrhea—but very few stop taking it because of these side effects.

People without diabetes who are overweight or obese and take a weekly 2.4 mg dose of semaglutide often get mild stomach issues like nausea, diarrhea, or vomiting, but most keep taking it — only a small number stop because of these side effects.

For people with heart disease, taking semaglutide means about 1 in 12 will stop treatment because of stomach problems like nausea or diarrhea — much more common than with a dummy pill.

If you're someone with obesity, taking a weekly shot called semaglutide might help lower your chances of having serious heart problems like heart attacks, strokes, or heart-related death, and could also reduce heart failure symptoms.