Mouse hair pigment cells move between different parts of the hair follicle and change their state back and forth, which is linked to WNT signaling.
Scientific Claim
In mice, melanocyte stem cell migration between hair follicle compartments is associated with reversible differentiation states influenced by WNT signaling.
Original Statement
“Live imaging and single-cell RNA sequencing revealed that McSCs are mobile, translocating between hair follicle stem cell and transit-amplifying compartments where they reversibly enter distinct differentiation states governed by local microenvironmental cues (for example, WNT).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Uses 'associated with' and 'influenced by' to avoid causal language, aligning with the study's non-causal evidence level.
Evidence from Studies
Supporting (1)
Dedifferentiation maintains melanocyte stem cells in a dynamic niche