When mouse hair is repeatedly plucked, more pigment cells get stuck in the bulge area (from 10% to 50% of follicles), and these stuck cells don't help make new hair color.
Scientific Claim
In mice subjected to repetitive hair regeneration, the percentage of hair follicles containing melanocyte stem cells in the bulge region increases from approximately 10% to over 50%, which is associated with reduced contribution to melanocyte regeneration.
Original Statement
“the percentage of HFs containing bulge McSCs increased from 10% to more than 50% (Fig. 4d). ... telogen bulge McSCs, which do not directly contribute to bulb melanocyte regeneration, increase during HF ageing induced by repetitive hair regeneration.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Uses 'associated with' and includes specific percentage data, avoiding causal language as required for non-causal evidence.
Evidence from Studies
Supporting (1)
Dedifferentiation maintains melanocyte stem cells in a dynamic niche