Taking 300-600mg of NAC daily is enough for most people to get benefits without side effects; higher doses don't help much more.
Scientific Claim
N-acetylcysteine supplementation at 300-600 mg/day provides optimal benefits for most individuals, with diminishing returns at higher doses and potential gastrointestinal side effects.
Original Statement
“For most people, 300 to 600 milligrams per day is enough to get the benefits without any GI issues. More is not always better. In fact, if you start taking too much, there's only a line of diminishing return. Okay? So, I would recommend keeping it under 600 millig unless you're dealing with some kind of acute respiratory thing, in which case sometimes going higher might help you out.”
Context Details
Domain
pharmacology
Population
human
Subject
N-acetylcysteine (NAC) supplementation
Action
provides
Target
optimal benefits at 300-600 mg/day for most individuals, with diminishing returns at higher doses and potential gastrointestinal side effects
Intervention Details
Evidence from Studies
Supporting (2)
Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study.
Investigation of the effect of N-acetylcysteine on serum levels of oxidative inflammatory biomarkers in patients with stroke