Nicotine alone can reduce hunger, even though smoking is bad because of other chemicals.
Evidence from Studies
Supporting (4)
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The appetite‐suppressant effect of nicotine is enhanced by caffeine *
This study found that nicotine alone (without smoking) makes people feel less hungry and more full, which supports the idea that nicotine itself, not just smoke, suppresses appetite.
A cholinergic basal forebrain feeding circuit modulates appetite suppression
The study found that activating certain brain cells that respond to nicotine reduces eating and leads to weight loss by sending signals to the part of the brain that tells you you're full—so nicotine likely works the same way, even without the other stuff in cigarettes.
GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity
This study found that nicotine, when given with a weight-loss drug, makes mice eat less by activating brain areas that tell them they’re full—without using any tobacco chemicals.
Nicotinic acetylcholine receptor signaling in the hypothalamus: mechanisms related to nicotine's effects on food intake.
This study shows that nicotine, on its own, tricks the brain’s hunger center into feeling full, even without the other chemicals in cigarettes. That’s exactly what the claim says.
Contradicting (1)
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The study gave rats nicotine without tobacco smoke and found it didn’t change their appetite hormones, which suggests nicotine might not be suppressing hunger the way the claim says.