People with obesity or type 2 diabetes who take a drug called retatrutide are more likely to get stomach issues like nausea, throwing up, or constipation—especially if they take higher doses (8 or 12 mg per week). But most people don’t have to stop taking it because of serious side effects.

Taking a weekly shot of retatrutide might make you feel more nauseous, throw up, get constipated, or have allergic reactions than if you took a fake shot — but these side effects aren’t life-threatening and are kind of expected.

When people with obesity take retatrutide, the most common side effects are stomach problems like nausea or diarrhea. These tend to happen more and get worse when the dose is higher, but starting with a lower dose (2 mg) might help reduce these issues.

Retatrutide, a diabetes drug, helped nearly 6 out of 10 adults lose at least 15% of their body weight in less than a year — way more than another drug called dulaglutide, which only helped 2 out of 10 people hit that goal.

Adults with obesity or type 2 diabetes who take a weekly 12 mg dose of retatrutide are way more likely—over 70 times more—to lose at least 15% of their body weight in less than a year compared to those taking a fake pill.

People with obesity who took a shot called retatrutide once a week for a year lost nearly a quarter of their body weight—way more than those who got a dummy shot. This makes it one of the strongest weight-loss medicines we’ve seen so far.