People with obesity or type 2 diabetes who take tirzepatide are much more likely to lose a meaningful amount of weight—like 5%, 10%, or even 15% of their body weight—compared to those who don’t, and...

People with obesity or type 2 diabetes who took a drug called tirzepatide lost a lot of weight—more when they took higher doses—and the effect lasted up to about three years.

Over 36 months, tirzepatide lowered body weight and blood sugar levels more than dulaglutide in adults with type 2 diabetes and heart disease, while both drugs had similar effects on cardiovascular safety.

In people with type 2 diabetes, the medication tirzepatide at 10 mg and 15 mg improves how the body responds to insulin more than can be explained by weight loss alone, suggesting other biological mechanisms are involved.

In adults who are overweight or obese but do not have diabetes, tirzepatide lowers both body mass index and blood sugar levels compared to other similar medications.

A new weight-loss drug called tirzepatide might help people with obesity lose about 23% of their body weight in a year and a half — possibly even more than some weight-loss surgeries.