High genetic susceptibility, as measured by polygenic risk scores, synergistically amplifies the risk of spondyloarthritis, type 1 diabetes, and psoriasis in the presence of high allostatic load, resulting in a disease risk greater than the sum of their individual effects.

Source: Allostatic load elevates the risk and adverse prognosis of immune-mediated inflammatory diseases: modulatory effects of lifestyle interventions and genetic susceptibility

What the research says

Supports is higher

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Supports

59score

Challenges

0score

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How it works

1 study reviewed

In plain English

People with high genetic risk for spondyloarthritis, type 1 diabetes, or psoriasis have a higher disease risk when exposed to high levels of chronic physiological stress, compared to the risk from genetics or stress alone.

See the scientific wording

High genetic susceptibility, measured by polygenic risk scores, synergistically amplifies the risk of spondyloarthritis, type 1 diabetes, and psoriasis when combined with high allostatic load, indicating that genetic and environmental stress factors interact to increase disease risk beyond their individual effects.

Why this might work

People with inherited genetic variants that make their immune system more reactive experience stronger and longer-lasting inflammation when under chronic stress. This stress causes the body’s stress hormones to stop working properly, so inflammation doesn’t turn off. In those with high genetic risk, this leads to changes in how immune cells read their genes, making them overproduce inflammatory signals and attack the body’s own tissues, triggering diseases like spondyloarthritis, type 1 diabetes, and psoriasis.

Verified mechanismbased on 1 study

What the research says

1 study

Study: Allostatic load elevates the risk and adverse prognosis of immune-mediated inflammatory diseases: modulatory effects of lifestyle interventions and genetic susceptibility
People with a strong genetic tendency for certain autoimmune diseases get much sicker if they’re under long-term stress — the stress and genes team up to make the risk way higher than either one alone.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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