The Claim

Higher consumption of aspartame is associated with a 17% increased risk of cerebrovascular disease, with a hazard ratio of 1.17 (95% CI: 1.03–1.33), based on data from 103,388 adults in the NutriNet-Santé cohort.

Source: Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
66score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

People who consume more aspartame have a 17% higher risk of experiencing cerebrovascular disease, such as stroke or transient ischemic attack, compared to those who consume less, according to data from a large adult cohort study.

See the scientific wording

Higher consumption of aspartame is associated with a 17% increased risk of cerebrovascular disease, with a hazard ratio of 1.17 (95% CI: 1.03–1.33), based on data from 103,388 adults in the NutriNet-Santé cohort, indicating a specific link between this artificial sweetener and stroke or transient ischemic attack risk.

Why this might work

When aspartame is broken down in the body, it produces phenylalanine, aspartic acid, and methanol. These substances increase oxidative stress in blood vessels, damage the inner lining of arteries, and make blood more likely to clot, which can block blood flow to the brain and cause a stroke.

Suggested mechanismbased on 1 study

What the research says

1 study
  1. Study: Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort

    This big study found that people who ate or drank more products with aspartame (like diet soda) were more likely to have strokes or mini-strokes over time, even after accounting for other health habits.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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