Analysis Version
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History
Back to Study: Long-Term Calorie Restriction Enhances Cellular Qu...
correlational
37
Pro
0
Against

People who eat fewer calories for many years have more proteins in their muscles that help clean up damaged proteins and cell parts, which may help keep cells healthier.

Scientific Claim

Long-term calorie restriction in humans is associated with increased levels of molecular chaperones and autophagic mediators in skeletal muscle compared to control groups, which are involved in cellular protein quality control and removal of dysfunctional proteins and organelles.

Original Statement

“Our data indicate that CR in humans is associated with sustained rises in serum cortisol, reduced inflammation, and increases in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles.”

From study:Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and only shows association, so 'associated with' is appropriate. The claim correctly states the finding without implying causation.

Evidence from Studies

Supporting (1)

37
37

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Cross-Sectional Study
Human

Contradicting (0)

0
No contradicting evidence found

Source Study

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Score: 37
DOI: 10.1016/j.celrep.2015.12.042

Similar Assertions

People who eat fewer calories for many years have more proteins in their muscles that help clean up damaged proteins and cell parts, which might explain why calorie restriction could slow aging.

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People who eat fewer calories for many years have more of a protein called LC3 in their muscles, which is involved in the process of cleaning up damaged cell parts.

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People who eat fewer calories for many years have more of a protein called beclin-1 in their muscles, which helps start the process of cleaning up damaged cell parts.

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People who eat fewer calories for many years have less inflammation in their muscles compared to people who don't restrict calories, which may help keep muscles healthier.

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People who eat fewer calories for many years have more of a protein called HSP70 in their muscles, which helps cells handle stress better.

37
0
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