People who eat fewer calories for many years have more proteins in their muscles that help clean up damaged proteins and cell parts, which may help keep cells healthier.

Scientific Claim

Long-term calorie restriction in humans is associated with increased levels of molecular chaperones and autophagic mediators in skeletal muscle compared to control groups, which are involved in cellular protein quality control and removal of dysfunctional proteins and organelles.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and only shows association, so 'associated with' is appropriate. The claim correctly states the finding without implying causation.

Source Excerpt

“Our data indicate that CR in humans is associated with sustained rises in serum cortisol, reduced inflammation, and increases in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles.”

Evidence from Studies

Supporting Evidence (1)

Why it supports

The abstract states that CR is associated with increases in molecular chaperones and autophagic mediators involved in cellular quality control. This is a direct observation without causal inference.

Score

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Cross-Sectional Study

Supported

Source Study

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Score: 37

DOI: 10.1016/j.celrep.2015.12.042

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